Large Animal Models of Cell-Free Cardiac Regeneration

Large animal models for cardiac stem cell therapies.

Cardiovascular disease is the leading cause of death in developed countries and is one of the leading causes of disease burden in developing countries. Therapies have markedly increased survival in several categories of patients, nonetheless mortality still remains high. For this reason high hopes are associated with recent developments in stem cell biology and regenerative medicine that promis...

Cardiac regeneration using pluripotent stem cells--progression to large animal models.

Pluripotent stem cells (PSCs) have indisputable cardiomyogenic potential and therefore have been intensively investigated as a potential cardiac regenerative therapy. Current directed differentiation protocols are able to produce high yields of cardiomyocytes from PSCs and studies in small animal models of cardiovascular disease have proven sustained engraftment and functional efficacy. Therefo...

Stem cells in animal models of regeneration

Animal Models of Cardiac Disease and Stem Cell Therapy

Animal models that mimic cardiovascular diseases are indispensable tools for understanding the mechanisms underlying the diseases at the cellular and molecular level. This review focuses on various methods in preclinical research to create small animal models of cardiac diseases, such as myocardial infarction, dilated cardiomyopathy, heart failure, myocarditis and cardiac hypertrophy, and the r...

Animal models of cardiac arrhythmias.

1. Introduction contributed to the development of diagnostic and therapeutic strategies. When surveying the literature with the intention of evaluating to which extent studies on animal models have contributed to the understanding of arrhythmia mecha-2. Supraventricular arrhythmias nisms in patients and in devising therapeutic strategies, one is struck by the differences between supraventricula...